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KMID : 1100720220420020141
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Annals of Laboratory Medicine
2022 Volume.42 No. 2 p.141 ~ p.149
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Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing
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Shin Sae-Am
Woo Hye-In
Kim Jong-Won
Kim Yoon-Jung
Lee Kyung-A
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Abstract
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Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this review, we provide evidence-based clinical practice guidelines for pre-analytical phase procedures of plasma epidermal growth factor receptor gene (EGFR) variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing.
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KEYWORD
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Cell-free nucleic acid, Circulating tumor DNA, Pre-analytical phase, Epidermal growth factor receptor, Clinical practice guidelines
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